MUMBAI: Universal Pictures' Despicable Me 2 continues to rake it in around the globe. The animated sequel surpassed the $800 million mark with Friday's estimated domestic grosses of $349.9 million and $451.4 million international bringing the worldwide take to $801.3 million.

The Universal and Illumination Entertainment pic has opened at No.1 in 45 territories and is the second highest grossing pic of 2013 worldwide behind Iron Man 3. Domestically it's No.2 and internationally only third behind Iron Man 3 and Fast & Furious 6.

Last month NBCUniversal chief Steve Burke declared Despicable Me 2 the studios' most profitable film in history; it's also Uni's second highest grosser of all time worldwide behind Jurassic Park.