MUMBAI: The multiple Emmy-winning NBC series Frasier ended its phenomenal run on Thursday.The one hour-long final episode had moments of slapstick comedy, warm emotional moments and a subtle romantic twist.

The episode ended with Frasier's brother Niles and Niles' wife Daphne getting their first child and the family patriarch Martin Crane getting married to Ronee. Frasier will be leaving Seattle to accept a new job in San Francisco.

"The reason I'm leaving is because I want what all of you have right now -- a new chapter," said an emotional Frasier.

Kelsey Grammer, who immortalised the lead character Prof. Frasier Crane in the five-time Emmy winner, had earlier hinted that his long-running character might return on another television series.

Now, even the Frasier show has ended leaving the fans guessing about a possible spin-off.